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1.
Heliyon ; 10(4): e25932, 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38370260

RESUMO

In this study, it was aimed to evaluate the effect of ethanol extract of Annona Muricata (AM) leaves in the prevention of brain damage caused by ionizing radiation (IR). This study was conducted in the Experimental Animal Research Unit of a university with 28 adults female Wistar Albino rats. The experimental groups were as follows: Control group (n = 8), AM group (n = 6), IR group (n = 8), AM + IR group (n = 6). In the IR group, astrocyte hypertrophy, microglial reaction and inflammatory reaction levels were significantly higher than the control and AM groups (P < 0.001). Edema was significantly higher in the IR group compared to the control group (P=0.001). The MDA of the IR group was significantly higher compared to the control group and AM group (P=0.031, P=0.006, respectively). The MDA of the AM + IR group was significantly higher than the AM group (P=0.039). Our findings show that histomorphology and oxidant damage caused by IR can be ameliorated using AM, as demonstrated by the comparison of the controls to AM + IR recipients, which showed similar histomorphology and oxidant damage levels.

2.
Heliyon ; 9(11): e21678, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38027855

RESUMO

The Pseudomonas aeruginosa OG1 strain was used in the bacterial synthesis of MgSe compound nanoparticles. The obtained samples were subsequently shaped into nanocrystalline MgSe films, and their optical, structural, morphological, and electrical properties were assessed on glass and p-Si substrates. Structural and morphological characterizations showed that the fabricated thin film samples have a polycrystalline structure with high quality and uniform grain sizes. The MgSe films produced on glass substrates exhibit a direct spectral band gap of 2.53 eV, according to optical measurements. The Ag/MgSe/p-Si layered diode structure was fabricated using the produced MgSe nanoparticles and then characterized by electrical properties. Electrical measurements were carried out under these two conditions to assess the effects of dark and illumination conditions on the band dynamics of the heterostructure devices. Under illumination, the barrier height decreased while the interface density states distribution increased. These measurements showed that using bacterial-assisted grown MgSe nanocrystalline films, the developed Ag/MgSe/p-Si device structure exhibited a remarkable photoresponse and stable rectifying property. Green synthesis methods for the production of these nanocrystalline materials have the potential to offer low-cost alternatives for photosensitive applications.

3.
Mar Pollut Bull ; 197: 115737, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37918140

RESUMO

A study was conducted to determine the 137Cs activity concentrations in various seaweed and mussel samples from the North East Mediterranean Sea, including the brown algae (Dictyota dichotoma) and oarweed (Laminaria digitata), and mussel species (Haliotis asinina, Mytilus edulis and Mytilus galloprovinciali). The 137Cs activity concentration in seaweed species exhibited varying levels, ranging from 84.20 ± 1.82 to 236.05 ± 5.72 mBq kg-1 fresh weight (fw) for oarweed, and 106.29 ± 2.26 to 252.38 ± 6.04 mBq kg-1 fw for brown algae. The 137Cs value in mussel species were between 12.94 ± 0.51-101.84 ± 1.35 mBq kg-1 fw for M. galloprovincialis, 15.49 ± 0.58-71.52 ± 1.16 mBq kg-1 fw for M. edulis, and 10.36 ± 0.11-69.13 ± 1.34 mBq kg-1 fw for H. asinine. When comparing the 137Cs concentration in seaweed and mussel species, the average concentration in seaweeds was approximately four times higher than that in mussels. This significant difference in radioisotope concentration highlights the potential for higher bioaccumulation of 137Cs in seaweeds compared to mussels.


Assuntos
Mytilus edulis , Mytilus , Alga Marinha , Animais , Mar Mediterrâneo
4.
Heliyon ; 9(9): e19745, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37809960

RESUMO

Magnesium ferrite (MgFe2O4) and polyethylene glycol (PEG) are materials known for their versatility in various applications. This study presents a comprehensive comparative analysis of the electrical conductivity and dielectric relaxation of nanostructured MgFe2O4 and its composites with PEG. Through experimentation, it was observed that incorporating PEG into MgFe2O4 did not lead to a high relative observed decrease or increase in electrical conductivity at room temperature. The study revealed that the composites maintained stable electrical behavior at room temperature, with a dielectric constant value of around 9 and a loss tangent value of around 0.1 at high frequency (around 7 MHz). The electron-hole hopping mechanism was identified as the underlying cause for the strong dielectric dispersion with frequency. The low dielectric loss and conductivity of the MgFe2O4 and PEG/ferrite composites make them promising candidates for high-frequency switching applications and microelectronic devices, particularly in scenarios where negligible eddy currents are essential. Additionally, complex impedance data analysis demonstrated that the capacitive and resistive properties of the composites are primarily attributed to grain boundary processes. This study provides a comprehensive analysis of the electrical and dielectric properties of MgFe2O4 and PEG composites and highlights their potential for many applications in materials science, particularly in electrical and electronic devices.

5.
Mar Pollut Bull ; 195: 115522, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37714072

RESUMO

This research presents the levels and distribution of 210Po in different sediments of the northeastern coast of the Mediterranean Sea. The 210Po activity concentrations were measured using an alpha spectroscopy system. The activity concentrations of 210Po in the sediment samples were in the range between 20.5 ± 0.7 and 92.8 ± 1.6 Bq kg-1 dw with an average of 48.2 ± 1.4 Bq kg-1 dw. The microorganism-enriched sampling sites (bedrock sites) indicated low 210Po concentration than sandy coastal sites. As a result of these measurements, the RESidual RADioactivity (RESRAD) biota code was applied to calculate the tissue concentration rate (CR), internal dose rate, external dose rate, and total dose rate of the exposed tissues. The total dose rates of aquatic animals were found higher than that of riparian animals. The 210Po sediment resource doses to aquatic and riparian animals were found less than the dose level recommended by International Commission on Radiological Protection (ICRP).

6.
Mar Pollut Bull ; 195: 115527, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37714075

RESUMO

A radiological baseline survey was conducted using a calculation analysis to assess the 226Ra, 232Th, 40K, and 137Cs distribution in beach sand samples collected from the coastal areas of the Mediterranean Sea. An analysis of the activity concentration of selected radionuclides was conducted. No evidence of recent migration of radiocaesium was found through precipitation, as well as indirect pathways, such as ocean runoff. The activity concentration of 226Ra, 232Th, 40K and 137Cs in beach sands ranged from 12 ± 1 to 37 ± 4 Bq kg- 1 (mean of 26 ± 3 Bq kg- 1); 18 ± 2 to 71 ± 8 Bq kg- 1 (mean of 40 ± 5 Bq kg- 1); 411 ± 10 to 720 ± 16 Bq kg- 1 (mean of 572 ± 12 Bq kg- 1); and 0.8 ± 0.1 to 3.1 ± 0.6 Bq kg- 1 (mean of 1.9 ± 0.3 Bq kg- 1), respectively. The radiological risk assessment showed that in all cases the values were lower than those that endanger life and safe work.

7.
Environ Res ; 238(Pt 2): 117188, 2023 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-37775007

RESUMO

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants (POPs) associated with diseases including osteoporosis, altered immune function and cancer. However, few studies have investigated the association between PFAS mixture exposure and Depression in general populations. METHODS: Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) (2005-2018) were used to analyze the association between PFAS and Depression in U.S. adults. Total 12,239 adults aged 20 years or older who had serum PFAS measured and answered Patient Health Questionnaire-9 (PHQ-9) were enrolled in this study. PFAS monomers detected in all 7 investigation cycles were included in the study. Generalized additive model (GAM) was used to fit smooth curves and threshold effect analysis was carried out to find the turning point of smooth curves. Generalized linear model (GLM) was used to describe the non-linear relationship between PFAS and depression and unconditioned logistic regression was used to risk analysis. RESULTS: The median of total serum PFAS concentration was 14.54 ng/mL. The curve fitting results indicated a U-shaped relationship between total serum PFAS and depression: PFAS< 39.66 ng/mL, A negative correlation between PHQ-9 score and serum PFAS concentration was observed (ß 0.047,95%CI -0.059, -0.036). The depression PHQ-9 score decreased with the increase of serum PFAS concentration. PFAS ≥ 39.66 ng/mL, A positive correlation was observed between PFAS and PHQ-9 score (ß 0.010,95% CI 0.003, 0.017). The depression PHQ-9 score increased with the increase of serum PFAS concentration. CONCLUSIONS: Our study provides new clues to the association of PFAS with depression, and large population-based cohort studies that can validate the causal association as well as toxicological mechanism studies are needed for validation.


Assuntos
Ácidos Alcanossulfônicos , Poluentes Ambientais , Fluorocarbonos , Humanos , Adulto , Estudos Transversais , Inquéritos Nutricionais , Depressão
8.
Chemosphere ; 342: 140108, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37714480

RESUMO

Nanoplastics have been widely studied as environmental pollutants, which can accumulate in the human body through the food chain or direct contact. Research has shown that nanoplastics can affect the immune system and mitochondrial function, but the underlying mechanisms are unclear. Lungs and macrophages have important immune and metabolic functions. This study explored the effects of 100 nm PS-NPs on innate immunity, mitochondrial function, and cellular metabolism-related pathways in lung (BEAS-2B) cells and macrophages (RAW264.7). The results had shown that PS-NPs exposure caused a decrease in mitochondrial membrane potential, intracellular ROS accumulation, and Ca2+ overload, and activated the cGAS-STING signaling pathway related to innate immunity. These changes had been observed at concentrations of PS-NPs as low as 60 µg/mL, which might have been comparable to environmental levels. Non-target metabolomics and Western Blotting results confirmed that PS-NPs regulated prostaglandin B1 and other metabolites to cause cell damage through the cGAS-STING pathway. Supplementation of prostaglandin B1 alleviated the immune activation and metabolic disturbance caused by PS-NPs exposure. This study identified PS-NPs-induced innate immune activation, mitochondrial dysfunction, and metabolic toxicity pathways, providing new insights into the potential for adverse outcomes of NPs in human life.

9.
RSC Adv ; 13(38): 26879-26891, 2023 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-37692354

RESUMO

Nanosized spinel ferrites Co1-xNixFe2O4 (where x = 0.0-1.0) or CNFO have been produced using a chemical method. The crystal structure's characteristics have been determined through the utilization of X-ray diffraction (XRD). It has been demonstrated that all samples have a single phase with cubic syngony (space group Fd3̄m). The lattice parameter and unit cell volume behavior correlate well with the average ionic radii of Co2+ and Ni2+ ions and their coordination numbers. Thus, an increase in the Ni2+ content from x = 0.0 to x = 1.0 leads to a decrease in the lattice parameter (from 8.3805 to 8.3316 Å) and unit cell volume (from 58.86 to 57.83 Å3). Elastic properties have been investigated using Fourier transform infrared (FTIR) analysis. The peculiarities of the microwave properties have been analyzed by the measured S-parameters in the range of 8-18 GHz. It was assumed that the energy losses due to reflection are a combination of electrical and magnetic losses due to polarization processes (dipole polarization) and magnetization reversal processes in the region of inter-resonant processes. A significant attenuation of the reflected wave energy (-10 … -21.8 dB) opens broad prospects for practical applications.

10.
J Adv Res ; 2023 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-37541584

RESUMO

BACKGROUND: p53 wild-type lung cancer cells can develop radiation resistance. Circular RNA (circRNA) consists of a family of transcripts with exclusive structures. circRNA is critical in tumorigenesis and is a potential biomarker or therapeutic target. It is uncertain how circRNA expression and functions are regulated post-radiation in p53 wild-type cancer cells. METHODS: A549 or H1299 cells were divided into p53-wt and p53-KO groups by CRISPR/Cas9; both groups were subjected to 4 Gy ionizing radiation (IR: p53-wt-IR and p53-KO-IR). RNA-seq, CCK8, cell cycle, and other functional and mechanism experiments were performed in vivo. p53 gene knockout mice were generated to test the cell results in vitro. RESULTS: circRNAs were found in differential groups. circRNA_0006420 (IRSense) was upregulated in p53-wt cells but had the same expression level as p53-KO cells after radiation, indicating that p53 silencing prevents its upregulation after IR. In the presence of p53, upregulated IRSense post-radiation induces G2/M arrest by regulating DNA damage repair (DDR) pathway-related proteins. Meanwhile, upregulated IRSense post-radiation aggravates the radiation-induced epithelial-mesenchymal transition (EMT). Interestingly, in the presence of p53, it promotes IRSense/HUR/PTBP1 complex formation resulting in the promotion of the radiation-induced EMT. Moreover, c-Jun regulates the upregulation of p53 transcription after radiation treatment. For these lung cancer cells with p53, upregulated IRSense aggravates lung cancer cell proliferation and increases radiation resistance by interacting with HUR (ElAV-like protein 1) and PTBP1 (polypyrimidine tract-binding protein 1) in the nucleus. CONCLUSIONS: Lung cancer cells retaining p53 may upregulate circRNA_0006420 (IRSense) expression post radiation to form an IRSense/HUR/PTBP1 complex leading to radiotherapy resistance. This study furthers our understanding of the roles of circRNA in regulating the effect of radiotherapy and provides novel therapeutic avenues for effective clinical lung cancer therapies.

11.
Heliyon ; 9(8): e18912, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37600407

RESUMO

WO3 effects on neutron and ionizing radiation defending factors of ternary tellurite-based glass blocks with molecular formula 80TeO2 -(20-x)WO3 - xK2O; x = 0-20 mol% (denoted as TKW-glass) has been reported via Phy-X theoretical calculations and Geant4 simulation code. Correlations between shielding factors and kinetics properties of the investigated glasses at different photon energy have been examined. The highest values of mass (MAC) attenuation coefficient were noted at 15 keV of the examined TKW-glass materials with the values of 38.408, 44.388, 49.855, 54.872, 59.492 cm2/g for TKW-0, TKW-5, TKW-10, TKW-15, and TKW-20, respectively. Generally, these values of the TKW-glasses obey the sequence: (TKW-0)MAC< (TKW-5)MAC < (TKW-10)MAC < (TKW-15)MAC < (TKW-20)MAC. The highest mean free path (MFP) values of TKW-glasses were registered at 15 MeV with the values of 6.101, 5.591, 5.097, 4.647, and 4.302 cm for TKW-0, TKW-5, TKW-10, TKW-15, and TKW-20, respectively. The two parameters half value layer (HVL) and MFP follow the pattern: (TKW-0)HVL, MFP > (TKW-5)HVL,MFP > (TKW-10)HVL,MFP > (TKW-15)HVL,MFP > (TKW-20)HVL,MFP. The maximum values of effective atomic number (EAN) took place at gamma energy of 15 keV corresponding to 44.35, 48.86, 52.63, 55.83, and 58.58 for TKW-0, TKW-5, TKW-10, TKW-15, and TKW-20, respectively. The trend of the buildup factors was similar for all of the glass specimens. The fast neutron removal cross-section (ΣR) enhanced as WO3 content increased in the specimens. Thus, the peaked value of ΣR is 0.1059 cm-1 was noted in the TKW-20 sample. Mechanical properties, neutron and γ-rays protection parameters were observed to improve with enhanced WO3 mol% in the TKW-glasses. The current results bear their utilization for neutron and gamma protection purposes.

12.
PLoS One ; 18(8): e0287422, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37535632

RESUMO

The utilization of phosphorite deposits as an industrial resource is of paramount importance, and its sustainability largely depends on ensuring safe and responsible practices. This study aims to evaluate the suitability of phosphorite deposits for industrial applications such as the production of phosphoric acid and phosphatic fertilizers. To achieve this goal, the study meticulously examines the geochemical characteristics of the deposits, investigates the distribution of natural Radioactivity within them, and assesses the potential radiological risk associated with their use. The phosphorites are massive and collected from different beds within the Duwi Formation at the Hamadat mining area. They are grain-supported and composed of phosphatic pellets, bioclasts (bones), non-phosphatic minerals, and cement. Geochemically, phosphorites contain high concentrations of P2O5 (23.59-28.36 wt.%) and CaO (40.85-44.35 wt.%), with low amounts of Al2O3 (0.23-0.51 wt.%), TiO2 (0.01-0.03 wt.%), Fe2O3 (1.14-2.28 wt.%), Na2O (0.37-1.19 wt.%), K2O (0.03-0.12 wt.%), and MnO (0.08-0.18 wt.%), suggesting the low contribution of the detrital material during their deposition. Moreover, they belong to contain enhanced U concentration (55-128 ppm). They are also enriched with Sr, Ba, Cr, V, and Zn and depleted in Th, Zr, and Rb, which strongly supports the low detrital input during the formation of the Hamadat phosphorites. The high Radioactivity of the studied phosphorites is probably due to the widespread occurrence of phosphatic components (e.g., apatite) that accommodate U in high concentrations. Gamma spectrometry based on NaI (Tl) crystal 3×3 has been used to measure occurring radionuclides in the phosphorite samples. The results indicate that the radioactive concentrations' average values of 226Ra, 232Th, and 40K are 184.18±9.19, 125.82±6.29, and 63.82±3.19 Bq Kg-1, respectively. Additionally, evaluations have been made of the radiological hazards. The calculated risk indicators exceeded the recommended national and world averages. The data obtained will serve as a reference for follow-up studies to evaluate the effectiveness of the Radioactivity of phosphatic materials collected from the Hamdat mine area.


Assuntos
Monitoramento de Radiação , Radioatividade , Rádio (Elemento) , Tório/análise , Radioisótopos de Potássio/análise , Monitoramento de Radiação/métodos , Compostos Férricos/análise
13.
Mar Pollut Bull ; 194(Pt B): 115367, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37567130

RESUMO

The objective of this study is to assess the natural resources and radiological risks of Wadi El Gemal Island by examining its topography, mineralogy, geochemistry, and radioactive distributions. This island, which is situated at the outlet of Wadi El Gemal in Egypt's southeastern Desert, has a unique shape resembling a dolphin based on Landsat imagery. It's a part of the Wadi El Gemal-Hamata Protectorate and is notable for its diverse environmental, geological, economic, and archeological features, including recent reefs, sandy deposits, Quaternary carbonate sediments, and mangroves. The main natural resources on the island are fauna, mangrove forests, and flora. Samples collected from the island were analyzed using a NaI detector to measure the concentrations of radionuclides such as 238U, 232Th, 226Ra, and 40K, which were found to be within acceptable levels according to UNSCAR guidelines. The radionuclide 238U, 232Th, 226Ra, and 40K activity concentrations of the collected samples were 32.55 ± 9, 12.63 ± 4, 12.49 ± 4, and 325 ± 34 Bq/kg, respectively. Regarding radiological hazard indices, the values of absorbed gamma dose rate (36.06 ± 5.42 nGy/h), radium equivalent activity (73.88 ± 14.4 Bq/kg), annual effective dose indoor (0.18 ± 0.03 mSv/y) and outdoor (0.04 ± 0.01 mSv/y), internal (0.29 ± 0.05) and external (0.2 ± 0.03) indices, and excess lifetime cancer index (0.15 ± 0.05 × 10-3).This is suggest that there is no significant risk associated with these sediments.


Assuntos
Monitoramento de Radiação , Radioatividade , Rádio (Elemento) , Poluentes Radioativos do Solo , Radioisótopos/análise , Rádio (Elemento)/análise , Recursos Naturais , Tório/análise , Poluentes Radioativos do Solo/análise , Radioisótopos de Potássio/análise , Espectrometria gama
14.
Heliyon ; 9(7): e17838, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37456003

RESUMO

We report the functional assessment of tungsten (VI) oxide on gamma-ray attenuation properties of 60Sb2O3-(40-x)NaPO3-xWO3 antimony glasses. The elemental mass-fractions and glass-densities of each glass sample are specified separately for the MCNPX Monte Carlo code. In addition to fundamental gamma absorption properties, Transmission Factors throughout a broad radioisotope energy range were measured. According to findings, holmium (Ho) incorporation into the glass structure resulted in a net increase of 0.3406 g/cm3, whereas cerium (Ce) addition resulted in a net increase of 0.2047 g/cm3. The 40% WO3 reinforced S7 sample was found to have the greatest LAC value, even though seven glass samples exhibited identical behavior. The S2 sample had the lowest HVL values among the glass groups evaluated in this work, computed in the energy range of 0.015-15 MeV. The lowest EBF and EABF values were reported for 40% WO3 reinforced S7 sample with the highest LAC and density values. According to the findings of this research, WO3 will likely make a significant contribution to the gamma ray absorption properties of antimony glasses, which are employed for optical and structural modification. Therefore, it can be concluded that WO3 may be treated monotonically and can be employed successfully in circumstances where gamma-ray absorption characteristics, optical properties, and structural qualities need to be enhanced.

15.
Mar Pollut Bull ; 193: 115166, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37348277

RESUMO

A combined hydrodynamic/radiobiological model was used to calculate the distribution and dose rate of significant radionuclides in the Mediterranean Sea marine organisms in the event of an accident at the Akkuyu Nuclear Power Plant (ANPP). The Hybrid single-particle Lagrangian integrated trajectory (HYSPLIT) model was applied to simulate the dispersion and deposition of artificial radionuclide concentrations. Environmental Risk from Ionising Contaminants: Assessment and Management (ERICA) tools were utilized to assess issues related to sea health and potential hazards in case of an accident. The scenario source term profile was derived from the Fukushima nuclear power accident. Volumetric concentrations and deposition levels of pollutants increased from 1 MBqm-3 to 1 × 103 MBqm-3 and from 1 × 10-1 MBqm-2 to 1 × 10-7 MBqm-2 after 48 h. In terms of dose rates to the various marine biotas, polychaete worms had the greatest overall dose rate and the highest contribution to total dose rates attributable to 137Cs radionuclide.


Assuntos
Acidente Nuclear de Fukushima , Monitoramento de Radiação , Poluentes Radioativos da Água , Mar Mediterrâneo , Centrais Nucleares , Radioisótopos de Césio/análise , Poluentes Radioativos da Água/análise , Biota , Japão
16.
Mar Pollut Bull ; 192: 115096, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37271076

RESUMO

The concentrations of heavy metals in the surface waters and sediments of Bitter Lake were investigated to assess the level, distribution, and source of pollution and the associated ecological and human health risks. The ecological indices of the lake water indicate low contamination degrees by heavy metals. A dermal exposure-based health risk evaluation revealed no carcinogenic or non-carcinogenic impact on human health. The contamination factor (CF) for Cu, Ni, Pb, Mn, Fe, and Zn (CF < 1) indicate low contamination levels, while Cd reaches very high contamination in most sediment sites (CF ranges from 6.2 to 72.4). Furthermore, the potential ecological risk factor (Eri) and modified hazard quotient (mHQ) indicate low ecological risk for all metals except Cd, revealing high to very high-level ecological risk in most sites (Eri ranges from 185 to 2173 and mHQ from 1.8 to 6.3). This emphasizes the urgency of prompt actions to improve the environment in Bitter Lake.


Assuntos
Metais Pesados , Poluentes Químicos da Água , Humanos , Lagos , Egito , Cádmio , Sedimentos Geológicos , Monitoramento Ambiental , Poluentes Químicos da Água/análise , Metais Pesados/análise
17.
Biomedicines ; 11(4)2023 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-37189792

RESUMO

This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and analyzes the maximum amount of nuclear transformation per Bq intake for each organ. The retention time of the maximum nuclear transformation and the absorbed doses of the drug in various organs and tissues are also examined. Data from clinical and laboratory studies on radiopharmaceuticals are used to estimate the coefficients of transition. The accumulation and excretion of the radiopharmaceutical in the organs is assumed to follow an exponential law. The coefficients of transition from the organs to the blood and vice versa are estimated using a combination of statistical programs and digitized data from the literature. WinAct and IDAC 2.1 software are used to calculate the distribution of the radiopharmaceutical in the human body and to estimate the absorbed doses in organs and tissues. The results of this study can provide valuable information for the biokinetic modeling of wide-spectrum diagnostic radiopharmaceuticals. The results show that 89Zr-oxalate has a high affinity for bones and a relatively low impact on healthy organs, making it helpful in targeting bone metastases. This study provides valuable information for further research on the development of this drug for potential clinical applications.

18.
Heliyon ; 9(4): e14881, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37025762

RESUMO

We report the critical optical properties such as Average Visible Transmittance (AVT), colour, Color Rendering Index (CRI), and Correlated Color Temperature (CCT) of a multicomponent glass system with a nominal composition of 50TeO2-30B2O3-(20-x)Li2O-xCeO2 (x = 0,0.5,1,2,3,4,5,10,15,20 mol%). Various advanced theoretical approaches as well as calculations are utilized in terms of determining the optical properties of studied glasses. The maximum transmittance and AVT values of the glass system exceeded 80% and 79.59%, respectively. The colour coordinates are found extremely near to D65 and the achromatic point without CeO2 contribution. According to our results, the current system has a promising ability to be utilized for coloured window applications in terms of both AVT and colour with 2% CeO2 doping. Our results showed that, the CeO2 additive is able to move the glass colour straight into the red spectrum by shifting the transmittance spectrum to the long-wavelength portion of the visible spectrum. With 10% CeO2 doping, opacity in the visible area and permeability in the NIR region are obtained, and the CCT value changes from 5002 K to 2560 K. It can be concluded that a filter system with modifiable NIR or red optical characteristics may be produced through the CeO2 alterations in borotellurite glass systems.

19.
Materials (Basel) ; 16(8)2023 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-37109873

RESUMO

Solar cells in superstrate arrangement need a protective cover glass as one of its main components. The effectiveness of these cells is determined by the cover glass's low weight, radiation resistance, optical clarity, and structural integrity. Damage to the cell covers brought on by exposure to UV irradiation and energetic radiation is thought to be the root cause of the ongoing issue of a reduction in the amount of electricity that can be generated by solar panels installed on spacecraft. Lead-free glasses made of xBi2O3-(40 - x)CaO-60P2O5 (x = 5, 10, 15, 20, 25, and 30 mol%) were created using the usual approach of melting at a high temperature. The amorphous nature of the glass samples was confirmed using X-ray diffraction. At energies of 81, 238, 356, 662, 911, 1173, 1332, and 2614 keV, the impact of various chemical compositions on gamma shielding in a phospho-bismuth glass structure was measured. The evaluation of gamma shielding revealed that the results of the mass attenuation coefficient of glasses increase as the Bi2O3 content increases but decrease as the photon energy increases. As a result of the study conducted on the radiation-deflecting properties of ternary glass, a lead-free low-melting phosphate glass that exhibited outstanding overall performance was developed, and the optimal composition of a glass sample was identified. The 60P2O5-30Bi2O3-10CaO glass combination is a viable option for use in radiation shielding that does not include lead.

20.
Heliyon ; 9(3): e14274, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36950638

RESUMO

This study's primary objective is to provide the preliminary findings of novel research on the design of Indium (III) oxide-reinforced glass container that were thoroughly developed for the purpose of a nuclear material container for transportation and waste management applications. The shielding characteristics of an Indium (III) oxide-reinforced glass container with a certain elemental composition against the 60Co radioisotope was thoroughly evaluated. The energy deposition in the air surrounding the designed portable glass containers is measured using MCNPX general-purpose Monte Carlo code. Simulation studies were carried out using Lenovo-P620 workstation and the number of tracks was defined as 108 in each simulation phase. According to results, the indium oxide-doped C6 (TZI8) container exhibits superior protective properties compared to other conventional container materials such as 0.5Bitumen-0.5 Cement, Pb Glass composite, Steel-Magnetite concrete. In addition to its superiority in terms of nuclear safety, it is proposed that the source's simultaneous observation and monitoring, as well as the C6 (TZI8) glass structure's transparency, be underlined as significant advantages. High-density glasses, which may replace undesirable materials such as concrete and lead, provide several advantages in terms of production ease, non-toxic properties, and resource monitoring. In conclusion, the use of Indium (III) oxide-reinforced glass with its high transparency and outstanding protection properties may be a substantial choice in places where concrete is required to ensure the safety of nuclear materials.

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